Sleep and Mood

By Pure Encapsulations Supports cellular and neuronal health to promote memory, emotional well-being, and cognitive function*. Acetyl-l-carnitine is the acetylated form of l-carnitine, the two compounds share similar energy and metabolism promoting properties. Found naturally in the body, acetyl-l-carnitine supports the availability of acetyl-CoA, an important energy generating metabolite. Also, it supports healthy mitochondrial function and cell membrane stability. A multicenter trial of 481 volunteers indicated memory, behavioral, and emotional support with acetyl-l-carnitine supplementation.* • Supports memory and attention* • Made with hypoallergenic, vegan ingredients

SAMe (S-adenosylmethionine), a compound native to the body, is a critical component of many biochemical reactions, including those that affect brain biochemistry and joint health.* Numerous studies have indicated that SAMe can help to alleviate transient normal aches and pains resulting from overexertion or stress.* In addition, because SAMe is also necessary for the synthesis of neurotransmitters, it plays an important role in the maintenance of a positive mood.* • Supports Nervous System and Joint Health* • Stabilized SAMe, Capsule Form • No Enteric Coating Needed

Enhances serotonin synthesis to support emotional well-being and restful sleep* The essential amino acid l-tryptophan is a serotonin precursor. Research indicates that l-tryptophan supplementation may support emotional well-being and restful sleep. In a double-blind, placebo-controlled study, l-tryptophan supported healthy emotional processing and promoted positive outlook in women. In a separate study, it supported healthy mood and lessened occasional irritability during the menstrual cycle. l-Tryptophan also supports healthy sleep quality, onset and duration. Additional research suggests that tryptophan may promote relaxation and help control occasional cravings. Vitamin B6 provides enhanced support as important cofactors involved in the metabolism of l-tryptophan.* • Supports emotional well-being and restful sleep* • Promotes healthy sleep quality, onset and duration* • Made with hypoallergenic, vegan ingredients

Promotes positive mood, supports relaxation and moderates occasional stress* GABA is the primary inhibitory neurotransmitter in the central nervous system, playing a central role in regulating cell-to-cell communication. Healthy levels have been associated with a positive mood. A recent study indicates that GABA also supports alpha wave production in the brain to promote relaxation and moderate occasional stress. In the same study, it supported healthy IgA levels, suggesting that it may support immune health during occasional stress.* • Helps moderate occasional stress* • Regulates cell-to-cell communication* • Made with hypoallergenic, vegan ingredients

Supports cellular and neuronal health to promote memory, emotional well-being, and cognitive function*. Acetyl-l-carnitine is the acetylated form of l-carnitine, the two compounds share similar energy and metabolism promoting properties. Found naturally in the body, acetyl-l-carnitine supports the availability of acetyl-CoA, an important energy generating metabolite. Also, it supports healthy mitochondrial function and cell membrane stability. A multicenter trial of 481 volunteers indicated memory, behavioral, and emotional support with acetyl-l-carnitine supplementation.* • Supports memory and attention* • Made with hypoallergenic, vegan ingredients

Promotes brain serotonin levels to support emotional well-being, healthy eating behavior, and healthy sleep*. 5-Hydroxytryptophan (5-HTP) is an intermediate in the natural synthesis of the essential amino acid, tryptophan, to serotonin. The enzyme tryptophan hydroxylase adds a hydroxyl group (OH) to tryptophan, forming the 5-HTP intermediate. In the body, it converts to serotonin with the removal of a carboxyl group (COOH) by a second enzyme. Serotonin is an important neurotransmitter involved in the regulation of endocrine and brain activity responsible for emotion, appetite, and sleep/wake cycles. In clinical studies, the administration of 5-HTP supported serotonin production. The 5-HTP supplied in this supplement is derived from the Griffonia simplicifolia plant.* • Promotes enhanced serotonin levels* • May improve emotional well-being, appetite control, and sleep/wake cycles* • Made with hypoallergenic, vegan ingredients

Promotes brain serotonin levels to support emotional well-being, healthy eating behavior, and healthy sleep*. 5-Hydroxytryptophan (5-HTP) is an intermediate in the natural synthesis of the essential amino acid, tryptophan, to serotonin. The enzyme tryptophan hydroxylase adds a hydroxyl group (OH) to tryptophan, forming the 5-HTP intermediate. In the body, it converts to serotonin with the removal of a carboxyl group (COOH) by a second enzyme. Serotonin is an important neurotransmitter involved in the regulation of endocrine and brain activity responsible for emotion, satiety, and sleep/wake cycles. In clinical studies, the administration of 5-HTP supported serotonin production. The 5-HTP supplied in this supplement is derived from the Griffonia simplicifolia plant.* • Promotes healthy serotonin levels* • Supports emotional well-being, satiety, and sleep/wake cycles* • Made with hypoallergenic, vegan ingredients

Supports the body's natural sleep cycle* Melatonin is a hormone produced by the pineal gland, which regulates the body's sleep/wake cycle. Melatonin’s primary role is regulation of the body's circadian rhythm, endocrine secretions, and sleep patterns. Studies indicate that it facilitates the onset of sleep, as well as sleep efficiency.* • Promotes the body's natural sleep cycle* • Helps augment the natural functioning of the pineal gland* • Made with hypoallergenic, vegan ingredients

PharmaGABA features a natural source of the inhibitory neurotransmitter GABA. GABA supports restful sleep, helps act like a ""brake"" on stress, and helps provide a focused state of mind.* Gamma-aminobutyric acid (GABA) is a major calming brain chemical or neurotransmitter.* Clinical studies show that the natural form of GABA that is in Thorne's PharmaGABA can help decrease the brain's stress-related beta waves and help increase the production of its alpha-waves, creating a sense of physical relaxation while maintaining mental focus.* Other studies have shown reduced pupil diameter, heart rate, and two natural biomarkers of stress salivary cortisol and chromogranin A all signs of relaxation.* In addition, studies also indicate GABA can support sleep.* In a head-to-head, double-blind trial of natural PharmaGABA versus synthetic GABA, the synthetic GABA did not demonstrate these supportive effects.* PharmaGABA-250 offers 250 mg of natural GABA per capsule, while PharmaGABA-100 offers 100 mg per capsule. Both are non-habit forming. Sleep* Sports Performance* Stress* Suggested Use Suggested Use: Take 1 capsule one to three times daily or as recommended by your health-care practitioner. Dietary Considerations Gluten Free Product Info Serving Size: 1 Capsule Servings Per Container: 60 Disclaimer Amount Per Serving Gamma-Aminobutyric Acid (GABA) 100 mg Other ingredients: Microcrystalline Cellulose, Hypromellose (derived from cellulose) capsule, Magnesium Citrate, Calcium Laurate Warnings Gluten Free Warning: If pregnant, nursing, or trying to conceive, consult your health-care practitioner before using this product. Tamper Evident: Use only if bottle is sealed. Store tightly sealed in a cool, dry place.

Cortisol Manager Allergen Free - The Stress Hormone Stabilizer Cortisol Manager Allergen Free is formulated with stress-reducing ingredients and botanicals to promote relaxation, help alleviate fatigue, and support healthy cortisol levels.* By balancing cortisol levels, Cortisol Manager Allergen Free helps reduce stress, which supports a restful nights sleep without diminishing daytime alertness.* The connection between Cortisol and Sleep: Cortisol production is generally at its peak in the early morning and gradually declines over the course of the day to its lowest point right before sleep. Cortisol awakening response (CAR), the natural rise in cortisol secretion immediately after awakening can be influenced and blunted by sleep quality and total sleep time. (Vargas 2014, Fekedulegen 2018) Trouble falling asleep, and frequent waking can be common with increased cortisol levels. (Vgontzas 2001) Cortisol, often referred to as the stress hormone, is produced by the adrenal cortex in response to signals from the hypothalamus and pituitary gland, as part of the hypothalamic-pituitary-adrenal (HPA) axis. Cortisol is perhaps the most important hormone involved in the adaptation process. Upon exposure to acute stressors, cortisol secretion can generally help maintain homeostasis in the body. Because of its central role as a first responder and its capability to modulate multiple critical physiological functions, cortisol is often seen as the bridge between stress and its health consequences. Cortisol Manager has been formulated with stress-reducing ingredients and botanicals to promote relaxation, help alleviate fatigue, and support healthy cortisol levels.* By balancing cortisol levels, Cortisol Manager Allergen Free can help reduce stress, which supports a restful night's sleep without diminishing daytime alertness.* Cortisol Manager Allergen Free is formulated with: Ashwagandha (Sensoril brand) L-theanine Magnolia Epimedium Phosphatidylserine Suggested Use Recommendation: For adults, take 1 capsule before bedtime, or as recommended by your healthcare professional. Increase to 2 capsules during times of high stress. For every night use. Dietary Considerations Wheat Free Dairy/ Milk Free Gluten Free Vegetarian Soy Free Yeast Free Sugar Free Preservative Free Salt Free Free of Artificial Colors/Flavors Egg Free Shellfish Free Fish Free Tree Nut Free Peanut Free Product Info Serving Size: 1 Vegetable Capsule Servings Per Container: 30 Disclaimer Amount Per Serving Stress-Reducing Proprietary Blend: 250 mg ashwagandha (Withania somnifera) (Sensoril brand) root and leaf extract L-theanine (Suntheanine brand) Cortisol-Reducing Proprietary Blend: 225 mg Magnolia (Magnolia officinalis) bark extract standardized to contain 2% honokiol and 1% magnolol epimedium (Epimedium spp.) aerial part extract SharpPS Green soy free phosphatidylserine 50 mg Other ingredients: hydroxypropyl methylcellulose (vegetable capsule), cellulose, silicon dioxide Warnings Contains no soy, wheat, gluten, eggs, peanuts, milk/dairy products, fish, tree nuts, shellfish, sugar, salt, yeast, ingredients of animal origin, or artificial flavors, or preservatives. Warning: Do not use if you are pregnant. If nursing, diabetic, or taking any prescription drugs, consult your healthcare professional prior to use. Keep out of reach of children. Safety sealed with a printed inner seal. Do not use if seal is broken or missing.

Formerly by Complementary Prescriptions Dietary Supplement, Formerly Cortisol Management Suggested Use Suggested Use: 1 capsule, 3 times daily with food or as directed by a healthcare professional. Dietary Considerations Wheat Free Dairy/ Milk Free Soy Free Preservative Free Free of Artificial Colors/Flavors Egg Free Shellfish Free Product Info Serving Size: 1 Capsule Servings Per Container: 90 Disclaimer Amount Per Serving Relora (Proprietary Blend of bark extracts of Magnolia officinalis and Phellodendron amurense) 250 mg Honokiol 4 mg Sensoril Ashwagandha Extract (Withania somnifera) (root and leaf) 85 mg Other ingredients: Starch, Vegetarian capsule (hydroxypropyl methylcellulose, water), water, Microcrystalline cellulose, Silicon dioxide Warnings Free of the following common allergens: milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat, and soybeans. Contains no artificial colors, flavors, or preservatives. Caution: If you are pregnant, nursing, have a medical condition, or taking prescription drugs, consult your healthcare professional before using this product. Keep out of reach of children.

The ability of the adrenal gland to respond to physiological stress is supported by botanicals with recognized adaptogenic properties. Eleuthero and rhodiola act on neurotransmitter function, the central nervous system, and cardiovascular function to help the body adjust appropriately when faced with biological, physical, or chemical challenges.* Cordyceps mushroom, known for its revitalizing effects, and pantothenic acid, a B vitamin required for adrenal hormone formation, are also included.* Suggested Use Suggested Use: 2 capsules, 2 times daily with food or as directed by a healthcare professional. Dietary Considerations Wheat Free Dairy/ Milk Free Soy Free Preservative Free Free of Artificial Colors/Flavors Egg Free Shellfish Free Product Info Serving Size: 2 Vegetable Capsule Servings Per Container: 60 Disclaimer Amount Per Serving Pantothenic Acid (as calcium D-pantothenate) 100 mg 2000% Cordyceps (Cordyceps sinensis) (mycelium) (standardized to 7% cordycepic acid) 400 mg Eleuthero Extract (Eleutherococcus senticosus) (root) (standardized to 0.8% eleutherosides) 200 mg Rhodiola Extract (Rhodiola rosea) (root) (standardized to 5% rosavins) 50 mg Other ingredients: Vegetarian capsule (hydroxypropyl methylcellulose, water), microcrystalline cellulose, ascorbyl palmitate, silicon dioxide Warnings Caution: If you are pregnant, nursing, have a medical condition, or taking prescription drugs, consult your physician before using this product. Keep out of reach of children. Do not use if shrinkwrap is broken or missing. Store in a cool, dry place (59F-85F) away from direct light.

Focused support for mitochondrial energy production.* The ability of mitochondria to sustain the high energy demands of the brain, liver, heart, muscles, endocrine glands, and other tissues can be compromised by many factors, including exposure to toxins, inadequate antioxidant intake, illness, genetic factors, and a decline in cellular function with increasing age. The accumulated effects of oxidative damage can disrupt mitochondrial membranes and damage lipids, DNA, and proteins, resulting in suboptimal functioning of affected organ systems. MitoThera supplies key nutrients and energy substrates to protect against free radicals and help assist mitochondria in performing their critical functions more efficiently.* Lecithin is excluded from MitoThera capsules for improved tolerance by those who are sensitive to soy. MitoThera augments the actions of MultiThera multivitamin formulas for individuals who need specialized nutritional support of energy metabolism and healthy aging. Suggested Use Suggested Use: 4 capsules daily with food or as directed by a healthcare professional. Dietary Considerations Wheat Free Dairy/ Milk Free Gluten Free Soy Free Yeast Free Preservative Free Free of Artificial Colors/Flavors Egg Free Shellfish Free Product Info Serving Size: 4 Vegetable Capsule Servings Per Container: 30 Disclaimer Amount Per Serving Magnesium (as magnesium malate complex) 45 mg 11% Sodium (as dissodium succinate) 85 mg 4% CoEnzyme Q10 (ubiquinone) 50 mg Acetyl-L-Carnitine (as acetyl-L-carnitine HCI) 200 mg N-Acetyl-L-Cysteine (NAC) 100 mg Alpha-Lipoic Acid 100 mg Creatine Monohydrate 200 mg Malic Acid (as magnesium malate complex) 195 mg Quercetin (as quercetin dihydrate) (derived from Japanese pagoda tree)(Sophora japonica) (flower extract) 125 mg Red Grape Extract (Vitis vinifera) (seed, skin, fruit/pulp)(full-spectrum phytonutrients, includes trans-resveratrol) 25 mg Succinic Acid (as disodium succinate) 215 mg Other ingredients: Vegetarian capsule (hydroxypropyl methylcellulose, water), water, L- leucine, microcrystalline cellulose, Silicon dioxide Warnings Caution: If you are pregnant, nursing, have a medical condition, or taking prescription drugs, consult your physician before using this product. Keep out of reach of children. Do not use if shrinkwrap is broken or missing. Store in a cool, dry place (59F-85F) away from direct light.

Formerly by Complementary Prescriptions Dietary Supplement Suggested Use Suggested Use: 1 capsule, 2 times daily with food or as directed by a healthcare professional. Dietary Considerations Wheat Free Dairy/ Milk Free Gluten Free Soy Free Yeast Free Preservative Free Corn Free Free of Artificial Colors/Flavors Shellfish Free Product Info Serving Size: 1 Capsule Servings Per Container: 120 Disclaimer Amount Per Serving Lithium (as lithium orotate) 4.8 mg Other ingredients: Microcrystalline cellulose, Vegetarian capsule (hydroxypropyl methylcellulose, water) Warnings Free of the following common allergens: milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat, soybeans, corn, and yeast. Contains no artificial colors, flavors, or preservatives. Caution: Individuals with renal or cardiovascular disease or who are taking diuretics or ACE inhibitors should consult their healthcare professional before use. Lithium should not be used by pregnant or nursing women. If you are pregnant, nursing, have a medical condition, or taking prescription drugs, consult your healthcare professional before using this product. Keep out of reach of children. Do not use if shrinkwrap is broken or missing. Store in a cool, dry place (59F-85F) away from direct light.

Designed to support healthy sleep patterns.* R.E.M is designed to support healthy sleep patterns.* It includes calming and soothing herbs and nutrients, along with support factors for serotonin and melatonin formation and function.* Select nutrients are provided to support mood and the body's natural sleep-awake rhythms.* Your patient's health is influenced by a good night's sleep.* See also 5 Hydroxy Tryptophan 50mg & 100mg, Gaba 500 & 5 Hydroxy Gaba. Suggested Use Take one (1) capsule daily, or as directed by your physician. Dietary Considerations Vegetarian Preservative Free Warnings Contains licorice root. Do not take during pregnancy. Consult your physician before using this product. WARNING: Contains licorice root. Do not take during pregnancy. Consult your physician before using this product. Contains no preservatives. Bisphenol-A (BPA) & Phthalate Free. Product info Serving Size: 1 Vegetable Capsule Servings Per Container: 30 Disclaimer Amount Per Serving Vitamin B6 (pyridoxine hcl) 4 mg Vitamin B12 (as cyanocobalamin) 100 mcg Pantothenic Acid (d-pantothenate) 20 mg Calcium (as calcium aspartate carbonate) 5 50 mg Magnesium (as magnesium malate oxide) 11.5 mg L-Glutathione 3 mg Hops (strobile) (ext. 4:1) (Humulus lupulus) 4 mg Lemon Balm (whole herb) (extract 4:1) (Melissa officinalis) 5 mg Melatonin 1 mg Inostiol 10 mg Griffonia simplicifolia (seed) (98% L-5-Hydroxytryptophan) 30 mg Peppermint (leaf) (extract 4:1) (Mentha piperita) 20 mg Jujube (seed) (Ziziphus jujuba) (2% Jujuboside) 10 mg L-Theanine 10 mg Licorice (root) (deglycyrrhizinated) (DGL) (Glycyrrhiza glabra) 6 mg GABA (gamma amino butyric acid) 50 mg DMG (dimethylglycine hcl) 50 mg MSM (methyl sulfonyl methane) 20 mg Phosphatidylserine 20% (SharpPSTM) 10 mg Other ingredients: Rice protein, gluten free maltodextrin, soy lecithin, silicon dioxide, tricalcium phosphate, ascorbyl palmitate, mixed tocopherols vegetarian capsule (hypromellose, purified water). Contains soy (phosphatidylserine)

Amino acid precursor and herbal combination A non-essential amino acid precursor and herbal combination designed to promote a positive mental state. Useful in promotinghealthy sleep patterns, and a calm relaxed state of mind.* Suggested Use Recommendations: Take one (1) capsule three (3) times daily, or as directed by your physician. Dietary Considerations Preservative Free Non-GMO Warnings Contains no preservatives, non-GMO. Bisphenol-A (BPA) & Phthialate Free Warning: If you are pregnant or breast feeding, consult your physician before taking this product. Keep container tightly closed, store in a cool dry place. Keep out of reach of children. Product info Serving Size: 1 Vegetable Capsule Servings Per Container: 90 Disclaimer Amount Per Serving Thiamine HCL (vitamin B1) 25 mg Niacinamide 25 mg Magnesium (as magnesium rice chelate oxide) 5 mg Inositol 175 mg Griffonia simplicifolia (seed) (L-5-Hydroxytryptophan 98%) 15 mg Valerian (root) (Valeriana officinalis) (standardized 0.8% valerenic acid) 15 mg Hops (strobiles)(Humulus lupulus) 50 mg Passionflower (leaf) (Passiflora incarnata) 25 mg L-Glutamic Acid 25 mg GABA (gamma amino butyric acid) 100 mg Other ingredients: Rice chelate, silicon dioxide, citric acid, vegetarian capsule (hypromellose, purified water).

The nutrients in Elo-plex are important for the normal body protection of adrenal cortex hormones (corticosteroids), adrenal medulla hormones (adrenalin and noradrenalin) and brain synthesis of catecholamine.* Suggested Use Directions: One to three capsules daily, or more, as directed by a doctor. Product info Serving Size: 1 Capsule Servings Per Container: 60 Disclaimer Amount Per Serving Vitamin C 100 mg Vitamin B-6 10 mg Pantothenic acid 50 mg Zinc (proteinate) 3.3 mg Copper (proteinate) 0.3 mg L-Tyrosine 150 mg DL-Phenylalanine 80 mg Adrenal 10 mg Hypothalamus 15 mg Other ingredients:

Now with PEAK ATP, this product provides immediately available ATP along with magnesium and malic acid essential in both aerobic and anaerobic reactions necessary for continued ATP production.* Suggested Use Directions: One capsule with a glass of water three times daily between meals on an empty stomach, or more, as directed by a doctor. Dietary Considerations Vegetarian Vegan Warnings Tamper evident band around cap and seal on bottle. Do not use if either seal is broken or missing. Keep out of reach of children. Contains no animal products. Product info Serving Size: 1 Vegetable Capsule Servings Per Container: 90 Disclaimer Amount Per Serving Magnesium (as Magnesium hydroxide) 100 mg Malic Acid 400 mg PEAK ATP 100 mg Other ingredients: Rice flour, hypromellose (vegetable capsule), vegetable magnesium stearate